BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//LRSS - Integrated research programme for non-animal safety assessment - ECPv4.7.2//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:LRSS - Integrated research programme for non-animal safety assessment
X-ORIGINAL-URL:https://www.lrsscosmeticseurope.eu
X-WR-CALDESC:Events for LRSS - Integrated research programme for non-animal safety assessment
BEGIN:VEVENT
DTSTART;VALUE=DATE:20191003
DTEND;VALUE=DATE:20191005
DTSTAMP:20260404T034437
CREATED:20190502T072214Z
LAST-MODIFIED:20190502T072214Z
UID:757-1570060800-1570233599@www.lrsscosmeticseurope.eu
SUMMARY:PBPK Modeling and quantitative in vitro-in vivo extrapolations
DESCRIPTION:Physiologically based pharmacokinetic (PBPK) modelling plays a crucial role in next generation (non-animal) risk evaluations to inform the design of in vitro studies and to convert the data obtained with in vitro models into human dose−response or potency information. The goal of the course is to acquaint participants with setting up PBPK models based on non-animal input parameters and to subsequently use these models to extrapolate in vitro bioassay data to human dose-response or potency information. \nThe course consists of: \n– Lectures that cover the basic principles of PBPK model-development and the application of PBPK modelling in different fields (e.g. safety evaluations of pharmaceuticals and industrial chemicals\, development of alternatives to animal testing). \n– Hands-on experience focussing on how to derive adequate chemical-specific input parameters. \n– Hands-on experience with developing PBPK models in Berkeley Madonna software. \n– Hands-on experience with developing PBPK models with Simcyp’s Population-based Simulator. \n– Use of the models to extrapolate in vitro bioassay results to human dose-response or potency information \nThe training will only take place if minimum of 8 participants is reached. \n
URL:https://www.lrsscosmeticseurope.eu/event/pbpk-modeling-and-quantitative-in-vitro-in-vivo-extrapolations/
LOCATION:RIKILT Wageningen University and Research\, Akkermaalsbos 2 6708\, Wageningen\, 6708\, Netherlands
CATEGORIES:Events
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