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Exposure

As part of its Long Range Science Strategy 2016-2020, Cosmetics Europe is working to explore scientifically robust methods for gathering representative cosmetic ingredient concentration data and assessing aggregate exposure to cosmetics ingredients with the aim to improve exposure assessment. With the present project, Cosmetics Europe will test the suitability of the existing Creme Global aggregate exposure system to model aggregate exposure of cosmetic chemicals.

The cosmetic ingredients under study in this part of the programme will be common to those being examined elsewhere within the LRSS program. This ensures that assessments of chemical hazard via read across and physiologically based pharmacokinetic (PBPK) models developed can be considered in tandem with robust exposure assessments, so that broader conclusions can be drawn on their overall safety and risk. For example, PBPK models can be linked to exposure models to generate estimates of internal exposure to chemicals (and Creme Global is currently involved in similar initiatives for agro-chemicals). Furthermore, this commonality of chemicals under study will facilitate future analyses that will integrate different models for risk assessment, and demonstrate the applicability of complete safety assessments in the absence of animal testing data.

To summarise, the main objectives of the proposed study are two-fold:

  1. Survey industry for chemical concentration data on ten substances
  2. Conduct a pilot study using the Creme Global aggregate exposure model on the ten case study substances.