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3Rs TOXICITY TESTING AND DISEASE MODELING PROJECTS IN THE EUROPEAN HORIZON 2020 RESEARCH AND INNOVATION PROGRAM
3Rs TOXICITY TESTING AND DISEASE MODELING PROJECTS IN THE EUROPEAN HORIZON 2020 RESEARCH AND INNOVATION PROGRAM
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File type: pdfADVANCING THE LONG RANGE SCIENCE STRATEGY WORK ON ALTERNATIVES POST-2020
COSMETICS EUROPE RESEARCH NEWSLETTER - ISSUE 3, JUNE 2019
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File type: pdfADVANCES IN GENOTOXICITY TESTING: A KEYSTONE OF OUR WORK ON ALTERNATIVES
COSMETICS EUROPE RESEARCH NEWSLETTER - ISSUE 2, JUNE 2017
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File type: pdfADVANCING RESEARCH INTO ALTERNATIVES FOR SKIN SENSITISATION AND TESTING STRATEGIES
COSMETICS EUROPE RESEARCH NEWSLETTER - ISSUE 1, JUNE 2016
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Finding synergies for the 3Rs – Repeated Dose Toxicity testing: Report from an EPAA Partners’ Forum
Charles Laroche a.b; Erwin Annys.c; Hans Bender.d; Danielle Botelho.e; Phil Botham.f; Susanne Brendler-Schwaab.g; Rick Clayton.h; Marco Corvaro.i; Gianni Dal Negro.j; Frédérique Delannois.j; Matt Dent.k; Christian Desaintes.l; Bertrand Desprez.m; Stephane Dhalluin.n; Andreas Hartmann.o; Simone Hoffmann-Doerr.p; Bruno Hubesch.q; Amaia Irizar.a; Mark T.D.Cronin.a.a;
READMOREUse of a simple in vitro test to assess loss of chemical due to volatility during an in vitro human skin absorption study
Grégoire S.a · Cubberley R.b · Duplan H.c · Eilstein J.a · Hewitt N.J.e · Jacques-Jamin C.c · Genies C.c · Klaric M.e · Rothe H.f · Ellison C.g · Fernandez J.h · Schepky A.d Published: 2019; Skin Pharmacol Physiol. 2019 Mar 19;32(3):117-124
READMOREA mode-of-action ontology model for safety evaluation of chemicals: Outcome of a series of workshops on repeated dose toxicity
B. Desprez, B. Birk, B. Blaauboer, A. Boobis, P. Carmichael, M. T.D. Cronin, R. Curie, G.Daston, B. Hubesch, P. Jennings, M. Klaric, D. Kroese, C. Mahony, G. Ouédraogo, A. Piersma, A.-N. Richarz, M. Schwarz, J. van Benthem, B. van de Water, M. Vinken , Toxicology in Vitro 59 (2019) 44–50
READMOREDevelopment of a defined approach for eye irritation or serious eye damage for liquids, neat and in dilution, based on cosmetics Europe analysis of in vitro STE and BCO
N. Alépée, E. Adriaens, T. Abo, D. Bagley, B. Desprez, J. Hibatallah, K. Mewes, U. Pfannenbecker, À. Sala, A.R. Van Rompay, S. Verstraelen, P. McNamee Toxicology in Vitro 57 (2019) 154–163
READMOREDevelopment of a defined approach for eye irritation or serious eye damage for neat liquids based on cosmetics Europe analysis of in vitroRhCE and BCOP test methods
N. Alépée, E. Adriaens, T. Abo, D. Bagley, B. Desprez, J. Hibatallah, K. Mewes, U. Pfannenbecker, À. Sala, A.R. Van Rompay, S. Verstraelen, P. McNamee Toxicology in Vitro 59 (2019) 100–114
READMOREWorkshop on the validation and regulatory acceptance of innovative 3R approaches in regulatory toxicology – Evolution versus revolution
T.Burgdorfa; A.H.Piersmabc; R.Landsiedeld, R.Clewelle; N.Kleinstreuerf; M.Oelgeschlägera; B.Desprezg; A.Kienhuisb; P.Bosh; R.de Vriesi; L.de With; T.Seidlej; J.Scheelk; G.Schönfelderan; J.van Benthemb; A.M.Vinggaardl; C.Eskesm; J.Ezendamb Toxicology in Vitro 59 (2019) 100–114
READMOREChallenges in working towards an internal threshold of toxicological concern (iTTC) for use in the safety assessment of cosmetics: Discussions from the Cosmetics Europe iTTC Working Group workshop
Corie A. Ellison, Karen L. Blackburn, Paul L. Carmichael, Harvey J. Clewell III., Mark T. D. Cronin, Bertrand Desprez, Sylvia E. Escher, Steve S. Ferguson, Sébastien Grégoire, Nicola J. Hewitt, Heli M. Hollnagel, Martina Klaric, Atish Patel, Sabrina Salhi, Andreas Schepky, Barbara G. Schmitt, John F. Wambaugh, Andrew Worth
READMOREA strategy for systemic toxicity assessment based on non-animal approaches: The Cosmetics Europe Long Range Science Strategy programme
2018 Bertrand Desprez, Matt Dent, Detlef Keller, Martina Klaric, Gladys Ouédraogo, RichardCubberley, Hélène Duplan, Joan Eilstein, Corie Ellison, Sébastien Grégoire, Nicola J.Hewitt, Carine Jacques-Jamin, Daniela Lange, Amy Roe, Helga Rothe, Bas J.Blaauboer, Andreas Schepky, Catherine Mahony Toxicol In Vitro. 2018 Aug;50:137-146.
READMOREState-of-the-art and new options to assess T cell activation by skin sensitizers: Cosmetics Europe Workshop
2018 Erwin van Vliet, Jochen Kühnl, Carsten Goebel, Silvia Martinozzi-Teissier, Nathalie Alépée, Takao Ashikaga, Brunhilde Blömeke, Aurélia Del Bufalo, Magalie Cluzel, Emanuela Corsini, Nathalie Delrue, Bertrand Desprez, Nichola Gellatly, Christoph Giese, Laura Gribaldo, Sebastian Hoffmann, Martina Klaric, Bernard Maillere, Dean Naisbitt, Marc Pallardy, Marc Vocanson, Dirk Petersohn ALTEX. 2017 Oct 2;35(2):179-192.
READMORENon-animal methods to predict skin sensitization (I): the Cosmetics Europe database
2018 Sebastian Hoffmann, Nicole Kleinstreuer, Nathalie Alépée, David Allen, Anne Marie Api,Takao Ashikaga, Elodie Clouet, Magalie Cluzel, Bertrand Desprez, Nichola Gellatly, Carsten Goebel, Petra S. Kern, Martina Klaric, Jochen Kühnl, Jon F. Lalko, Silvia Martinozzi-Teissier, Karsten Mewes, Masaaki Miyazawa, Rahul Parakhia, Erwin van Vliet, Qingda Zang & Dirk Petersohn Crit Rev Toxicol. 2018 May;48(5):344-358.
READMORENon-animal methods to predict skin sensitization (II): an assessment of defined approaches
2018 Nicole C. Kleinstreuer, Sebastian Hoffmann, Nathalie Alépée, David Allen, Takao Ashikaga, Warren Casey, Elodie Clouet, Magalie Cluzel, Bertrand Desprez, Nichola Gellatly, Carsten Göbel, Petra S. Kern, Martina Klaric, Jochen Kühnl, Silvia Martinozzi-Teissier, Karsten Mewes, Masaaki Miyazawa, Judy Strickland, Erwin van Vliet, Qingda Zang & Dirk Petersohn Crit Rev Toxicol. 2018 May;48(5):359-374.
READMOREWorkshop on acceleration of the validation and regulatory acceptance of alternative methods and implementation of testing strategies
A.H. Piersma, T. Burgdorf, K. Louekari, B. Desprez, R. Taalman, R. Landsiedel, J. Barroso, V. Rogiers, C. Eskes, M. Oelgeschläger, M. Whelan, A. Braeuning, A.M. Vinggaard, A. Kienhuis, J. van Benthem, J. Ezendam Toxicology in Vitro 50 (2018) 62–74
READMOREValidation of the 3D Skin Comet assay using full thickness skin models: Transferability and reproducibility
Reisinger K, Blatz V, Brinkmann J, Downs TR, Fischer A, Henkler F, Hoffmann S, Krul C, Liebsch M, Luch A, Pirow R, Reus AA, Schulz M, Pfuhler S.; Mutat Res. 2018 Mar;827:27-41
READMORESolvent Solubility Testing of Cosmetics-Relevant Chemicals: Methodology and Correlation of Water Solubility to In Silico Predictions
2017 S. Grégoire, R. Cubberley, H. Duplan, J. Eilstein, D. Lange, N. Hewitt, C. Jacques-Jamin, M. Klaric, H. Rothe, C. Ellison, O. Vaillant, A. Schepky J Solution Chem. 2017 Jul;46(7):1349-1363
READMOREComparison of the Skin Penetration of 3 Metabolically Stable Chemicals Using Fresh and Frozen Human Skin
2017 Jacques-Jamin C., Duplan H., Rothe H., Vaillant O., Eilstein J., Grégoire S., Cubberley R., Lange D., Ellison C., Klaric M., Hewitt N., Schepky A. Skin Pharmacol Physiol. 2017;30(5):234-245.
READMOREComparison of protocols measuring diffusion and partition coefficients in the stratum corneum
2017 H. Rothe, C. Obringer, J. Manwaring, C. Avci, W. Wargniez, J. Eilstein, N. Hewitt, R. Cubberley, H. Duplan, D. Lange, C. Jacques‐Jamin, M. Klaric, A. Schepky, S. Grégoire J Appl Toxicol. 2017 Jul;37(7):806-816.
READMOREComparison of protocols for measuring cosmetic ingredient distribution in human and pig skin
2016 D. Gerstela, C. Jacques-Jamin, A. Schepky, R. Cubberley, J. Eilstein, S. Grégoire, N. Hewitt, M. Klaric, H. Rothe, H. Duplan Toxicol In Vitro. 2016 Aug;34:153-60.
READMOREThe Cosmetics Europe strategy for animal-free genotoxicity testing: project status up-date
2014 Pfuhler S., Fautz R., Ouedraogo G., Latil A., Kenny J., Moore C. , Toxicol In Vitro 28(1):18-23.
READMOREReduction of misleading (“false”) positive results in mammalian cell genotoxicity assays. III: Sensitivity of human cell types to known genotoxic agents
2014 Fowler P., Smith R., Smith K., Young J., Jeffrey L., Carmichael P., Kirkland D., Pfuhler S., Mutat Res pii: S1383- 5718(14)00053-9. doi: 10.1016/j.mrgentox.2014.03.001.
READMORERetrospective Analysis of the Draize Test for serious eye damage/eye irritation: importance of understanding the in vivo endpoints under UN GHS / EU CLP for the development and evaluation of in vitro test methods
2014 Adriaens E., Barroso J., Eskes C., Hoffmann S., McNamee P., Alépée N., Bessou-Touya S., De Smedt A., De Wever B., Pfannenbecker U., Tailhardat M., Zuang V. , Archives of Toxicology 88, 701-723
READMORESystematic evaluation of non-animal test methods for skin sensitisation safety assessment (submitted/ review in progress)
2014 Reisinger K. and Hoffmann S., Alepee N., Ashikaga T., Barroso J. Elcombe C., Gellatly N., Galbiati V., Gibbs S., Groux H., Hibatallah J., KellerD., Kern P., Klaric M, Kolle S., Kuehnl J., Lambrechts N., Lindstedt M., Millet M., Martinozzi-Teissier S., Natsch A., Petersohn D., Pike I., Sakaguchi H., Schepky A., Tailhardat M., Templier M., van Vliet E., Maxwell G.,
READMOREUse of human in vitro skin models for accurate and ethical risk assessment: metabolic considerations
2013 Hewitt NJ, Edwards RJ, Fritsche E, Goebel C, Aeby P, Scheel J, et al. , Toxicol Sci 133(2):209-17.
READMOREComet assay in reconstructed 3D human epidermal skin models–investigation of intra- and inter-laboratory reproducibility with coded chemicals
2013 Reus AA., Reisinger K., Downs TR., Carr GJ., Zeller A., Corvi R., Krul CA., Pfuhler S. , Mutagenesis 28(6):709-20.
READMOREEvaluation of chemicals requiring metabolic activation in the EpiDerm™ 3D human reconstructed skin micronucleus (RSMN) assay
2013 Aardema MJ., Barnett BB., Mun GC., Dahl EL., Curren RD., Hewitt NJ., Pfuhler S., Mutat Res 750(1-2):40-9.
READMORECosmetics Europe multi-laboratory pre-validation of the SkinEthic™ reconstituted human corneal epithelium test method for the prediction of eye irritation
2013 Alépée N., Bessou-Touya S., Cotovio J., De Smedt A., De Wever B., Faller C., Jones P., LeVarlet B., Marrec-Fairley M., Pfannenbecker U., Tailhardat M., van Goethem F., McNamee P. , Toxicology In Vitro. 27, 619-626
READMORECosmetics Europe multi-laboratory pre- validation of the EpiOcular™ reconstituted human tissue test method for the prediction of eye irritation
2013 Pfannenbecker U., Bessou-Touya S., Faller C., Harbell J., Jacob T., Raabe H., Tailhardat M., Alépée N., De Smedt A., De Wever B., Jones P., Kaluzhny Y., Le Varlet B., McNamee P., Marrec-Fairley M., Van Goethem F. Toxicology In Vitro. 27, 619-626
READMORESkin sensitisation–moving forward with non-animal testing strategies for regulatory purposes in the EU Regulation
2013 Basketter D, Alépée N, Casati S, Crozier J, Eigler D, Griem P, Hubesch B, de Knecht J, Landsiedel R, Louekari K, Manou I, Maxwell G, Mehling A, Netzeva T, Petry T, Rossi LH Toxicol Pharmacol. 67:531-5
READMOREElucidation of xenobiotic metabolism pathways in human skin and human skin models by proteomic profiling
2012 van Eijl S, Zhu Z, Cupitt J, Gierula M, Götz C, Fritsche E, Edwards RJ. , PLoS One 7(7):e41721.
READMOREXenobiotic metabolism capacities of human skin in comparison with a 3D-epidermis model and keratinocyte-based cell culture as in vitro alternatives for chemical testing: phase II enzymes
2012 Götz C, Pfeiffer R, Tigges J, Ruwiedel K, Hübenthal U, Merk HF, et al. Exp Dermatol 21(5):364-9.
READMOREXenobiotic metabolism capacities of human skin in comparison with a 3D epidermis model and keratinocyte-based cell culture as in vitro alternatives for chemical testing: activating enzymes (Phase I)
2012 Götz C, Pfeiffer R, Tigges J, Blatz V, Jäckh C, Freytag EM, et al. Exp Dermatol 21(5):358-63.
READMOREGuiding principles for the implementation of non-animal safety assessment approaches for cosmetics: skin sensitisation
2012 Goebel C., et al.,Regul Toxicol Pharmacol. 2012 Jun;63(1):40-52. doi: 10.1016/j.yrtph.2012.02.007. Epub 2012 Feb 21.
READMOREEffects of the genotoxic compounds, benzo[a]pyrene and cyclophosphamide on phase 1 and 2 activities in EpiDerm™ model
2012 Götz C., Hewitt NJ., Jermann E., Tigges J., Kohne Z., Hübenthal U. , Xenobiotica 42(6):526-37.
READMOREReduction of misleading (“false”) positive results in mammalian cell genotoxicity assays. II. Importance of accurate toxicity measurement
2012 Fowler P., Smith R., Smith K., Young J., Jeffrey L., Kirkland D., Pfuhler S., Carmichael P. , Mutat Res 747(1):104-17.
READMORESkin exposure to deodorants/antiperspirants in aerosol form
2012 W. Steiling, P. Buttgereit, B. Hall, L. O’Keeffe , B. Safford, S. Tozer, M. Coroama,Food and Chemical Toxicology
READMOREGuiding Principles for the Implementation of Non-animal Safety Assessment Approaches for Cosmetics: Skin Sensitisation
2012 Goebel C, Aeby P, Ade N, Alépée N, Aptula A, Araki D, Dufour E, Gilmour N, Hibatallah J, Keller D, Kern P, Kirst A, Marrec-Fairley M, Maxwell G, Rowland J, Safford B, Schellauf F, Schepky A, Seaman C, Teichert T, Tessier N, Teissier S, Weltzien H. U., Winkler P, Scheel J. Reg Toxicol Pharmacol 63:40-52.
READMOREReduction of misleading (“false”) positive results in mammalian cell genotoxicity assays. I. Choice of cell type
2011 Fowler P., Smith K., Young J., Jeffrey L., Kirkland D., Pfuhler S., Carmichael P., Mutat Res 742(1-2):11-25.
READMOREThe reconstructed skin micronucleus assay (RSMN) in EpiDerm: detailed protocol and harmonized scoring atlas
2011 Dahl E.L, Curren R., Barnett BC., Khambatta Z., Reisinger K., Ouedraogo G. ,Mutat Res 720:42-52.
READMOREUpdate on the Colipa research programme for development of in vitro alternative methods for eye irritation ALTEX 28
2011 McNamee P., Declercq L., De Smedt A., De Wever B., Faller C., Harbell J., Jones P., Marrec-Fairley M., Pape W., Pfannenbecker U., Schroeder K., Tailhardat M., Van den Berghe C.and Van Goethem F
READMOREEuropean consumer exposure to cosmetic products, a framework for conducting population exposure assessments Part 2
2011 B. Hall , W. Steiling, B. Safford, M. Coroama, S. Tozer, C. Firmani, C. McNamara, M. Gibney, Food and Chemical Toxicology
READMOREMathematical models of skin permeability: An overview
2011 Mitragotri S, Anissimov YG, Bunge AL, Frasch HF, Guy RH, Hadgraft J, Int J Pharm.
READMORESkin sensitisation: the Colipa strategy for developing and evaluating non-animal test methods for risk assessment
2011 Maxwell G, Aeby P, Ashikaga T, Bessou-Touya S, Diembeck W, Gerberick F, ALTEX 28:50-5.
READMOREA tiered approach to the use of alternatives to animal testing for the safety assessment of cosmetics: genotoxicity A COLIPA analysis
2010 Pfuhler S., et al., Regul Toxicol Pharmacol. 2010 Jul-Aug;57(2-3):315-24. doi: 10.1016/j.yrtph.2010.03.012. Epub 2010 Apr 9.
READMOREA tiered approach to the use of alternatives to animal testing for the safety assessment of cosmetics: genotoxicity. A COLIPA analysis
2010 Pfuhler S., Kirst A., Aardema M., Banduhn N., Goebel C., Araki D. , Regul Toxicol Pharmacol 57:315-24.
READMOREFurther analysis of Ames-negative rodent carcinogens that are only genotoxic in mammalian cells in vitro at concentrations exceeding 1 mM, including retesting of compounds of concern
2010 Kirkland D., Fowler P., Mutagenesis 25:539-53.
READMOREInternational prevalidation studies of the EpiDerm 3D human reconstructed skin micronucleus (RSMN) assay: transferability and reproducibility
2010 Aardema MJ., Barnett BC., Khambatta Z., Reisinger K., Ouedraogo-Arras G., Faquet B. , Mutat Res 701:123-31.
READMOREProspective validation study of reconstructed human tissue models for eye irritation testing
2010 Freeman S.J., Alépée N., Barroso J., Cole T., Compagnoni A., Rubingh C., Eskes C., Lammers J., McNamee P., Pfannenbecker U., Zuang V. , ALTEX. 27 special issue, 261- 266
READMOREA proposed eye irritation testing strategy to reduce and replace in vivo studies using Bottom-Up and Top- Down approaches
2010 Scott L., Eskes C., Hoffmann S., Adriaens E., Alepee N., Bufo M., Toxicol In Vitro 24:1-9
READMOREPredicting skin sensitization potential and inter-laboratory reproducibility of a human Cell Line Activation Test (h-CLAT) in the European Cosmetics Association (COLIPA) ring trials
2010 Sakaguchi H, Ryan C, Ovigne JM, Schroeder KR, Ashikaga T, Toxicol In Vitro 24:1810-20.
READMOREResponsiveness of human monocyte-derived dendritic cells to thimerosal and mercury derivatives
2010 Migdal C, Tailhardat M, Courtellemont P, Haftek M, Serres M , Toxicol Appl Pharmacol 246:66-73.
READMORESensitization effect of thimerosal is mediated in vitro via reactive oxygen species and calcium signaling
2010 Migdal C, Foggia L, Tailhardat M, Courtellemont P, Haftek M, Serres M Toxicology 274:1-9.
READMOREEffect of a microemulsion system on hapten-peptide reactivity studies: examples of hydroxycitronellal and citral, fragrance skin sensitizers, with glutathione
2010 Merckel F, Bernard G, Mutschler J, Gimenez-Arnau E, Gerberick GF, Lepoittevin JP Chem Res Toxicol 23:1433-41.
READMORET-cell recognition of chemicals, protein allergens and drugs: towards the development of in vitro assays
2010 Martin SF, Esser PR, Schmucker S, Dietz L, Naisbitt DJ, Park BK, Cell Mol Life Sci 67:4171-84.
READMOREIdentifying and characterizing chemical skin sensitizers without animal testing: Colipa’s research and method development program
2010 Aeby P, Ashikaga T, Bessou-Touya S, Schepky A, Gerberick F, Kern P, Toxicol In Vitro 24:1465-73.
READMOREA tiered approach to the use of alternatives to animal testing for the safety assessment of cosmetics: eye irritation
2009 Mc Namee P., et al.,Regul Toxicol Pharmacol. 2009 Jul;54(2):197-209. doi: 10.1016/j.yrtph.2009.04.004. Epub 2009 Apr 22
READMOREA tiered approach to the use of alternatives to animal testing for the safety assessment of cosmetics: skin irritation
2009 MacFarlane M., et al.,Regul Toxicol Pharmacol. Jul;54(2):188-96. doi: 10.1016/j.yrtph.2009.04.003. Epub 2009 Apr 22.
READMOREFurther development of the EpiDerm 3D reconstructed human skin micronucleus (RSMN) assay
2009 Mun GC., Aardema MJ., Hu T., Barnett B., Kaluzhny Y., Klausner M. , Mutat Res 673:92-9.
READMOREIntralaboratory and interlaboratory evaluation of the EpiDerm 3D human reconstructed skin micronucleus (RSMN) assay
2009 Hu T., Kaluzhny Y., Mun GC., Barnett B., Karetsky V., Wilt N. , Mutat Res 673:100-8.
READMOREOvercoming barriers to validation of non-animal partial replacement methods/integrated testing strategies: The report of an EPAA-ECVAM workshop
2009 Kinser-Ovaskainen A., Akkan Z., Casati S., Coecke, S., Corvi, R., Dal Negro, G., De Bruijn, J., De Silva, O., Gribaldo, L., Griesinger, C., Jaworska, J., Kreysa, J., Maxwell, G., McNamee, P., Price, A., Prieto, P., Schubert, R., Tosti, L., Worth, A., Zuang, V. , ATLA. 37, 437-444
READMOREA tiered approach to the use of alternatives to animal testing for the safety assessment of cosmetics: Eye irritation
2009 McNamee P., Hibatallah J., Costabel-Farkas M., Goebel C., Araki D., Dufour E., Hewitt N .J., Jones P., Kirst A, Le Varlet B, Macfarlane M., Marrec-Fairley M., Rowland J., Schellauf F., Scheel J, Regulatory Toxicology and Pharmacology 54: 197-209
READMOREMechanistic assessment of peptide reactivity assay to predict skin allergens with Kathon CG isothiazolinones
2009 Mutschler J, Gimenez-Arnau E, Foertsch L, Gerberick GF, Lepoittevin JP, Toxicol In Vitro 23:439-46.
READMOREA tiered approach to the use of alternatives to animal testing for the safety assessment of cosmetics: Skin irritation
2009 Macfarlane M, Jones P, Goebel C, Dufour E, Rowland J, Araki D, Costabel-Farkas M, Hewitt N, Hibatallah J, Kirst A, McNamee P, Schellauf F, Scheel J, Regulatory Toxicology and Pharmacology 54: 188-196
READMOREInvestigation of peptide reactivity of pro-hapten skin sensitizers using a peroxidase-peroxide oxidation system
2009 Gerberick GF, Troutman JA, Foertsch LM, Vassallo JD, Quijano M, Dobson RL Toxicol Sci 112:164-74.
READMORESelection of chemicals for the development and evaluation of in vitro methods for skin sensitisation testing
2009 Casati S, Aeby P, Kimber I, Maxwell G, Ovigne JM, Roggen E, Altern Lab Anim 37:305-12.
READMOREDepletion of human peripheral blood lymphocytes in CD25+ cells allows for the sensitive in vitro screening of contact allergens
2008 Vocanson M, Cluzel-Tailhardat M, Poyet G, Valeyrie M, Chavagnac C, Levarlet B, J Invest Dermatol 128:2119-22.
READMORECharacterization of early events involved in human dendritic cell maturation induced by sensitizers: cross talk between MAPK signalling pathways
2008 Trompezinski S, Migdal C, Tailhardat M, Le Varlet B, Courtellemont P, Haftek M, Toxicol Appl Pharmacol 230:397-406.
READMOREA spreadsheet-based method for estimating the skin disposition of volatile compounds: application to N,N-diethyl- m-toluamide (DEET)
2008 Kasting GB, Miller MA, Bhatt VD J Occup Environ Hyg 5:633-44.
READMOREChemical reactivity measurement and the predicitive identification of skin sensitisers. The report and recommendations of ECVAM Workshop 64
2008 Gerberick F, Aleksic M, Basketter D, Casati S, Karlberg AT, Kern P, Altern Lab Anim 36:215-42.
READMOREHow to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: Report of an ECVAM Workshop
2007 Kirkland D., Pfuhler S., Tweats D., Aardema M., Corvi R., Darroudi F. , Mutat Res 628:31-55.
READMOREIn vitro approaches to develop weight of evidence (WoE) and mode of action (MoA) discussions with positive in vitro genotoxicity results
2007 Kirkland DJ., Aardema M., Banduhn N., Carmichael P., Fautz R., Meunier JR. , Mutagenesis 22:161-75.
READMOREProbabilistic modelling of European consumer exposure to cosmetic products, Food and Chemical Toxicology
2007 C. McNamara, D. Rohan, D. Golden, M. Gibney, B. Hall, S. Tozer, B. Safford, M. Coroama, M. Leveneu-Duchemin, W. Steiling,
READMOREEuropean consumer exposure to cosmetic products, a framework for conducting population exposure assessments, Food and Chemical Toxicology
2007 B. Hall, S. Tozer, B. Safford, M. Coroama, W. Steiling, M.C. Leneveu-Duchemin, C. McNamara, M. Gibney .
READMOREAssessment of the U937 cell line for the detection of contact allergens
2007 Python F, Goebel C, Aeby P , Toxicol Appl Pharmacol 220:113-24.
READMOREQuantification of chemical peptide reactivity for screening contact allergens: a classification tree model approach
2007 Gerberick GF, Vassallo JD, Foertsch LM, Price BB, Chaney JG, Lepoittevin JP Toxicol Sci 97:417-27.
READMOREPrevalidation of a new in vitro reconstituted human cornea model to assess the eye irritating potential of chemicals
2006 Van Goethem F., Adriaens E., Alepee N., Straube F., De Wever B., Cappadoro M., Toxicol In Vitro 20:1-17
READMOREIdentification of gene expression changes induced by chemical allergens in dendritic cells: opportunities for skin sensitization testing
2006 Gildea LA, Ryan CA, Foertsch LM, Kennedy JM, Dearman RJ, Kimber I, J Invest Dermatol 126:1813-22.
READMOREGene expression changes in peripheral blood-derived dendritic cells following exposure to a contact allergen
2004 Ryan CA, Gildea LA, Hulette BC, Dearman RJ, Kimber I, Gerberick GF , Toxicol Lett 150:301-16.
READMOREEvaluation of CD86 expression and MHC class II molecule internalization in THP-1 human monocyte cells as predictive endpoints for contact sensitizers
2002 Ashikaga T, Hoya M, Itagaki H, Katsumura Y, Aiba S . Toxicol In Vitro 16:711-6
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Better understanding of bioavailability of cosmetic ingredients: Results from Cosmetics Europe skin bioavailability project
Eurotox congress, September 2017
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File type: pdfState-of-the-art and new options to assess T cell activation by skin sensitizers
SOT meeting, March 2018
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File type: pdfCosmetics Europe evaluation of 6 in silico skin penetration models
SOT meeting, March 2018
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File type: pdfCosmetics Europe Analysis: Towards development of an ocular toxicity Defined Approach using in vitro test methods and physico-chemical properties as components within an IATA
SOT meeting, March 2018
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File type: pdfAn exposure-led safety assessment framework for systemic toxicity: initial case studies from Cosmetics Europe
SOT meeting, March 2018
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File type: pdfValidation and application of the 3D human reconstructed skin micronucleus assay (RSMN) using the EpiDermTM tissue to the safety assessment of cosmetics ingredients
World congress 10 on alternatives to animal testing, August 2017
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File type: pdfCosmetics Europe Eye Programme: Relevance to Integrated Approaches on Testing and Assessment for Serious Eye Damage/Eye Irritation
World congress 10 on alternatives to animal testing, August 2017
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File type: pdfTesting Strategies for UN GHS Classification for Serious Eye Damage/Eye Irritation of Chemicals: Cosmetics Europe Analysis
World congress 10 on alternatives to animal testing, August 2017
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File type: pdfThe importance of understanding physico-chemical properties of chemicals in the evaluation of serious eye damage/eye irritation: Cosmetic Europe analysis
World congress 10 on alternatives to animal testing, August 2017
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File type: pdfCosmetics Europe Long Range Science Strategy for Non-Animal Safety Assessments
World congress 10 on alternatives to animal testing, August 2017
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File type: pdfThe HET-MN (Hen’s Egg Test for Micronucleus-Induction): Promising pre-validation study
World congress 10 on alternatives to animal testing, August 2017
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File type: pdfBridging the gap from external to internal exposure: use of in silico, PBPK and in vitro methods to predict the biokinetics of topically applied cosmetic ingredients
World congress 10 on alternatives to animal testing, August 2017
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File type: pdfCosmetics Europe Assessment of Non-Animal Approaches for Predicting Skin Sensitization
Eurotox congress, September 2017
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File type: pdfIn-vitro-only testing strategies for cosmetic ingredients: Utility of newly validated genotoxicity assays using human skin and fertilized hen’s eggs
Eurotox congress, September 2017
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Cosmetics Europe LRSS Booklet
NON-ANIMAL APPROACHES TO SAFETY ASSESSMENT OF COSMETIC PRODUCTS Cutting-Edge Science and Constant Innovation: The Keys to Success
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File type: pdf
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